ECI 2016i: Sergio Santa María (investigador NASA) expondrá sobre Ciencias del Espacio & Biología

Sergio Santa María, investigador de la NASA Ames Research Center, expondrá sobre Ciencias del Espacio & Biologia en el Encuentro Científico Internacional 2016 de invierno (ECI 2016i) que va desde el 30 de julio al 1 de agosto.

Sergio Santa María es profesor asociado en la Universidad de New Mexico e investigador del proyecto BioSentinel de la NASA  . Tiene más de 10 años de experiencia en los campos de la biología molecular, la  radio-biología y la bioquímica .

Ha investigado en temas de biología molecular y genética, reparación y mutagénesis de ADN , la radiación cósmica, biosensores de radiación y la genómica de alto rendimiento .

Entre sus más recientes publicaciones se tiene:

Characterization of the interaction between the Saccharomyces cerevisiae Rad51 recombinase and the DNA translocase Rdh54.(Link)

The Journal of Biological Chemistry

June 24, 2013

The Saccharomyces cerevisiae Rdh54 protein is a member of the Swi2/Snf2 family of DNA translocases required for meiotic and mitotic recombination and DNA repair. Rdh54 interacts with the general recombinases Rad51 and Dmc1, and promotes D-loop formation with either recombinase. Rdh54 also mediates the removal of Rad51 from undamaged chromatin in mitotic cells, which prevents formation of…more

Mechanisms of DNA Recombination(Link)

In: Bell E., Bond J., Klinman J., Masters B., Wells R. (Ed.) Molecular Life Sciences: An Encyclopedic Reference. Springer-Verlag Berlin Heidelberg, 2013

October 11, 2012

DNA double strand breaks are one of the most deleterious forms of DNA damage and may arise from exposure to environmental agents or as intermediates during normal cellular processes. If left unrepaired, chromosome rearrangements and loss occur, which can lead to the uncovering of recessive mutations (loss of heterozygosity) and cell growth arrest, which can ultimately lead to cell death. Breaks…more

Homologous recombination in lesion bypass(Link)

In: Bell E., Bond J., Klinman J., Masters B., Wells R. (Ed.) Molecular Life Sciences: An Encyclopedic Reference. Springer-Verlag Berlin Heidelberg, 2013

October 5, 2012

Living cells possess a variety of repair pathways to cope with DNA damage; however, many lesions can escape repair and potentially block DNA replication and other cellular processes. Fortunately, cells have evolved mechanisms that allow the bypass or tolerance of these lesions for subsequent DNA repair. In eukaryotes, lesion bypass occurs primarily via the Rad6-Rad18-dependent and homologous…more

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors.(Link)

Nucleic Acids Research

August 2011

The Saccharomyces cerevisiae Swi2-like factors Rad54 and Rdh54 play multifaceted roles in homologous recombination via their DNA translocase activity. Aside from promoting Rad51-mediated DNA strand invasion of a partner chromatid, Rad54 and Rdh54 can remove Rad51 from duplex DNA for intracellular recycling. Although the in vitro properties of the two proteins are similar, differences between the…more

Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast.(Link)

MBio

May 2011

DNA lesions in the template strand block the replication fork. In Saccharomyces cerevisiae, replication through DNA lesions occurs via a Rad6/Rad18-dependent pathway where lesions can be bypassed by the action of translesion synthesis (TLS) DNA polymerases η and ζ or by Rad5-mediated template switching. An alternative Rad6/Rad18-independent but Rad52-dependent template switching pathway can also…more

 

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